Current Available Antiviral Agents

Current Available Antiviral Agents

Posted by Valerie Walters on Jul 4, 2020 2:54 pm

Antiviral agents are drugs that inhibit the spread of virus, for example by preventing replication of the genome, blocking entry to host cells, or inhibiting viral protein synthesis or viral assembly. The antiviral agents are a large and diverse group of agents that are typically classified by the virus infections for which they are used, their chemical structure and their mode of action.

Unlike other antimicrobials, antiviral drugs do not deactivate or destroy the microbe (in this case, the virus) but act by inhibiting replication. In this way, they prevent the viral load from increasing to a point where it could cause pathogenesis, allowing the body's innate immune mechanisms to neutralize the virus.

Currently, antiviral therapy is available only for a limited number of infections. Only a few antiviral drugs are reasonably safe and effective against a limited number of viral diseases, and most of these have been developed in people. Most antiviral agents have been developed in the last 20 to 25 years, many as a result of the major research efforts to develop therapies and means of prevention of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS).

The development of antiviral agents is not trivial as viral replication is intricately linked with the host cell that any antiviral drug that interferes even to a lesser extent with host cell factors may be toxic to the host depending on the duration and dosage used. Most antiviral drugs interfere with viral nucleic acid synthesis or regulation. Such drugs generally are nucleic acid analogues that interfere with RNA and DNA production. Other mechanisms of action include interference with viral cell binding or interruption of virus uncoating. Some viruses contain unique metabolic pathways that serve as a target of drug therapy.

Take the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing coronavirus disease 2019 (COVID-19) for example. The SARS-CoV-2 genome encodes approximately 25 proteins that are needed by the virus to infect humans and to replicate. Among these are the notorious spike (S) protein, which recognizes human angiotensin-converting enzyme 2 in the initial stage of infection; two proteases, which cleave viral and human proteins; the RNA polymerase, which synthesizes viral RNA; and the RNA-cleaving endoribonuclease. Finding drugs that can bind to the viral proteins and stop them from working is a logical way forward and the priority of many research laboratories.

Viral diseases represent a real challenge for modern medicine with the recent emergence of new viral threats worldwide such as Ebola, Avian Influenza, MERS, HIV/AIDS, SARS, and now SARS-CoV-2. Reliable sourcing of antiviral compounds remains crucial to support the effective research and development of new preventive and therapeutic cures and regimens to treat infectious diseases.
 
Name CAS URL
Zidovudine 30516-87-1 https://www.vulcanchem.com/product/inhibitors/VC1095523
Emtricitabine 143491-57-0 https://www.vulcanchem.com/product/inhibitors/VC1054181
Acyclovir 59277-89-3 https://www.vulcanchem.com/product/apis/59277-89-3
Ritonavir 155213-67-5 https://www.vulcanchem.com/product/apis/155213-67-5
Lamivudine 134678-17-4 https://www.vulcanchem.com/product/inhibitors/VC1064801
Ribavirin 36791-04-5 https://www.vulcanchem.com/product/inhibitors/VC1082765
Abacavir Sulfate 188062-50-2 https://www.vulcanchem.com/product/impurities/VC385823
Saquinavir 127779-20-8 https://www.vulcanchem.com/product/inhibitors/127779-20-8
Stavudine 3056-17-5 https://www.vulcanchem.com/product/inhibitors/VC1087889
Efavirenz 154598-52-4 https://www.vulcanchem.com/product/inhibitors/VC1053813
Nevirapine 129618-40-2 https://www.vulcanchem.com/product/inhibitors/VC1074139
Lopinavir 192725-17-0 https://www.vulcanchem.com/product/impurities/VC385935
Didanosine 69655-05-6 https://www.vulcanchem.com/product/inhibitors/VC1051975
Etravirine 269055-15-4 https://www.vulcanchem.com/product/inhibitors/VC1055247
Tenofovir Disoproxil Fumarate 202138-50-9 https://www.vulcanchem.com/product/inhibitors/VC1089845
Ganciclovir 82410-32-0 https://www.vulcanchem.com/product/apis/82410-32-0
Boceprevir 394730-60-0 https://www.vulcanchem.com/product/inhibitors/VC1097845
Amprenavir 161814-49-9 https://www.vulcanchem.com/product/inhibitors/VC1037621
Amantadine 768-94-5 https://www.vulcanchem.com/product/inhibitors/VC1036615
Saquinavir Mesylate 149845-06-7 https://www.vulcanchem.com/product/inhibitors/149845-06-7
Telaprevir 402957-28-2 https://www.vulcanchem.com/product/inhibitors/VC1098123
Rilpivirine 500287-72-9 https://www.vulcanchem.com/product/inhibitors/VC1097893
Zanamivir 139110-80-8 https://www.vulcanchem.com/product/inhibitors/VC1095385
Maraviroc 376348-65-1 https://www.vulcanchem.com/product/inhibitors/VC1069101
Idoxuridine 54-42-2 https://www.vulcanchem.com/product/inhibitors/VC1060827
Sofosbuvir 1190307-88-0 https://www.vulcanchem.com/product/inhibitors/VC1097859
Valganciclovir Hydrochloride 175865-59-5 https://www.vulcanchem.com/product/inhibitors/VC1093093
Valacyclovir Hydrochloride 124832-27-5 https://www.vulcanchem.com/product/inhibitors/VC1093035
Oseltamivir Phosphate 204255-11-8 https://www.vulcanchem.com/product/inhibitors/VC1076539
Ombitasvir 1258226-87-7 https://www.vulcanchem.com/product/inhibitors/VC1096991
Daclatasvir 1009119-64-5 https://www.vulcanchem.com/product/inhibitors/VC1049841
Atazanavir 198904-31-3 https://www.vulcanchem.com/product/inhibitors/VC1039285
Indinavir Sulfate 157810-81-6 https://www.vulcanchem.com/product/inhibitors/VC1061239
Atazanavir Sulfate 229975-97-7 https://www.vulcanchem.com/product/inhibitors/VC1039287
Adefovir 106941-25-7 https://www.vulcanchem.com/product/inhibitors/VC1034461
Nelfinavir Mesylate 159989-65-8 https://www.vulcanchem.com/product/inhibitors/VC1073893
Famciclovir 104227-87-4 https://www.vulcanchem.com/product/inhibitors/VC1055473
Indinavir 150378-17-9 https://www.vulcanchem.com/product/inhibitors/VC1061237
Raltegravir 518048-05-0 https://www.vulcanchem.com/product/inhibitors/VC1082057
Elvitegravir 697761-98-1 https://www.vulcanchem.com/product/inhibitors/VC1097879
Abacavir 136470-78-5 https://www.vulcanchem.com/product/inhibitors/VC1033405
Telbivudine 3424-98-4 https://www.vulcanchem.com/product/inhibitors/VC1089733
Amantadine Hydrochloride 665-66-7 https://www.vulcanchem.com/product/inhibitors/VC1036617
Tipranavir 174484-41-4 https://www.vulcanchem.com/product/inhibitors/VC1097865
Foscarnet Sodium 34156-56-4 https://www.vulcanchem.com/product/reference-standards/34156-56-4

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