Study finds existing drugs that could treat COVID-19

Study finds existing drugs that could treat COVID-19

Posted by Valerie Walters on Jul 29, 2020 8:00 am

A Nature study authored by a global team of scientists at Sanford Burnham Prebys Medical Discovery Institute, has identified 21 existing drugs that stop the replication of SARS-CoV-2, the virus that causes COVID-19.

The study reported a high-throughput analysis of approximately 12,000 known drugs evaluated for activity against SARS-CoV-2 replication, revealing approximately 100 known drugs with antiviral activities. Of these, 21 drugs were determined to be effective at concentrations that could be safely achieved in patients. Several major target classes were found to be enriched for activity in this analysis, including ion channels, GPCRs, proteases, and kinases. Notably, four of these compounds were found to work synergistically with remdesivir, a current standard-of-care treatment for COVID-19. The pharmacokinetic properties of each individual compound, including factors such as serum protein binding and bioavailability in the lung, will impact potential in vivo antiviral efficacy.

 

Dose relationship antiviral

 


Of the 21 drugs that were effective at blocking viral replication, the scientists found:

● 13 have previously entered clinical trials for other indications and are effective at concentrations, or doses, that could potentially be safely achieved in COVID-19 patients.

● Two are already FDA approved: astemizole (allergies), clofazamine (leprosy), and remdesivir has received Emergency Use Authorization from the agency (COVID-19).

● Four worked synergistically with remdesivir, including the chloroquine derivative hanfangchin A (tetrandrine), an antimalarial drug that has reached Phase 3 clinical trials.

List of the 21 most potent compounds validated in dose response across multiple cell lines reported by the study:

Compound Name Known Targets Target Class More Information
Clofazimine mycobacterial DNA (ABCB1) Unspecified https://www.vulcanchem.com/product/inhibitors/VC1048009
Astemizole Histamine H1 receptor GPCR https://www.vulcanchem.com/product/inhibitors/VC1039157
Remdesivir viral RNA polymerase Antiviral https://www.vulcanchem.com/product/inhibitors/VC1031201
Hanfangchin A (Tetrandrine) calcium channels (non-selective) Ion channel https://www.vulcanchem.com/product/inhibitors/VC1097651
Apilimod PIKfyve Phosphoinositide kinase https://www.vulcanchem.com/product/inhibitors/VC1038247
MLN-3897 C-C Motif Chemokine Receptor 1 (CCR1) GPCR https://www.vulcanchem.com/product/inhibitors/VC1071633
ONO 5334 cathepsin K (CTSK) Cysteine protease https://www.vulcanchem.com/product/inhibitors/VC1076253
Elopiprazole D2 and D3 dopamine receptors (DRD2, DRD3), 5-HT1A serotonin receptor (HTR1A) GPCR https://www.vulcanchem.com/product/main-products/115464-77-2
SDZ-62-434 PAF /PI3K/Akt/NF-kappaB pathway GPCR https://www.vulcanchem.com/product/inhibitors/VC1085773
YH-1238 H,K-ATPase (ATP4A, ATP4B) Proton Pump https://www.vulcanchem.com/product/inhibitors/VC1119549
DS-6930 PPARγ Nuclear receptor https://www.vulcanchem.com/product/inhibitors/VC1053343
N-tert-Butylisoquine (GSK369796) hERG potassium ion channel (KCNH2) Chloroquine derivative, Ion channel https://www.vulcanchem.com/product/inhibitors/VC1058903
R 82913 reverse transcriptase Antiviral https://www.vulcanchem.com/product/inhibitors/VC1081903
VBY-825 cathepsins B, L, S and V (CTSB, CTSL, CTSS, CTSV) Cysteine protease https://www.vulcanchem.com/product/inhibitors/1310340-58-9
8-(3-Chlorostyryl)caffeine A2A adenosine receptor (ADORA2A) GPCR https://www.vulcanchem.com/product/main-products/147700-11-6
AMG-2674 TRPV1 Ion channel https://www.vulcanchem.com/product/inhibitors/VC1119553
KW 8232 Prostaglandin Receptors GPCR https://www.vulcanchem.com/product/inhibitors/VC1119551
MDL 28170 Calpain I / II (CAPN1, CAPN2) Cysteine protease https://www.vulcanchem.com/product/reference-standards/88191-84-8
SB-616234-A 5-HT1B serotonin receptor (HTR1B) GPCR https://www.vulcanchem.com/product/inhibitors/908601-49-0
SL-11128 Unknown Unspecified https://www.vulcanchem.com/product/inhibitors/VC1119555
Z LVG CHN2 cysteine proteinase produced by group A streptococci Cysteine protease https://www.vulcanchem.com/product/main-products/119670-30-3

 

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