What Is Omapatrilat?

What Is Omapatrilat?

Posted by Ada Brown on May 30, 2016 10:55 am

Omapatrilat is an antihypertensive drug which acts by inhibiting angiotensin-converting enzyme (ACE) and neutral endopeptidase. ACE a zinc-containing carbopeptidase, catalyzes the conversion of the decapeptide angiotensin I (AI) to the octapeptide angiotensin II (AII). AII is a potent vasoconstrictor which also triggers the release of aldosterone, a sodium-retaining steroid. Thus ACE raises blood pressure by increasing both vascular resistance and fluid volume. Effective inhibitors of ACE have been used not only in the treatment of hypertension but in the clinical management of congestive heart failure. Neutral endopeptidase (NEP), like ACE, is a zinc metalloprotease and is found in high concentration in the brush border of the renal proximal tubule. NEP is highly efficient in degrading atrial natriuretic peptide (ANP), a 28-amino acid peptide secreted by the heart in response to atrial distension. 

Re: What Is Omapatrilat?

Posted by Yasmin Hussain on Jun 19, 2020 12:00 pm

From what I read, it’s an investigational drug. The inhibition of NEP elevates natriuretic peptide levels, increasing excretion of sodium in urine, dilating blood vessels, and reducing preload and ventricular remodeling. This drug from BMS was not approved by the FDA due to angioedema safety concerns.

Re: What Is Omapatrilat?

Posted by Tradeasia International on Jul 1, 2020 7:38 am

Omapatrilat is an investigational drug that inhibits both neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE). The inhibition of NEP elevates natriuretic peptide levels, increasing excretion of sodium in the urine, dilating blood vessels, and reducing preload and ventricular remodeling.

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