Cell-Penetrating Peptides

Cell-Penetrating Peptides

Posted by Annie Golden on Dec 22, 2016 6:40 am

Cell-Penetrating Peptides (CPPs), also known as protein transduction domains (PTDs) or membrane transduction peptides (MTPs) have been widely used for the intracellular uptake and delivery of various macromolecules, or "cargo", which are associated with the peptides either via covalent bond or through non-covalent interaction, such as TAT family peptides. As an attractive pharmaceutical and biochemical tool, CPPs can overcome the impermeable nature of cell membrane to facilitate the cellular penetration of potential drugs into mammalian cells. Applications of cell-penetrating peptides for delivering various macromolecules with biological functions into cells begin to come into vogue. 

Re: Cell-Penetrating Peptides

Posted by Yasmin Hussain on Jun 16, 2020 10:35 am

I also read that cell-penetrating peptides have potential to deliver a wide range of molecules, including large active proteins to enter cells via endocytosis. They’re mostly positively charged at physiological pH due to the presence of several arginine or lysine residues.

Re: Cell-Penetrating Peptides

Posted by Tradeasia International on Jul 3, 2020 8:57 am

Cell-penetrating peptides (CPPs) are short peptides that facilitate cellular intake and uptake of molecules ranging from nanosize particles to small chemical compounds to large fragments of DNA.

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