Chelate Peptides (DOTA related peptides)

Chelate Peptides (DOTA related peptides)

Posted by Annie Golden on Jan 25, 2017 8:35 am

Chelate Peptides (DOTA related peptides) are organic compounds and commonly used as a complexing agent, which have been widely used as contrast agents for cancer treatments. It can also be linked to molecules that have affinity to various structures (e.g. somatostatin receptors on neuroendocrine tumours). The generated compounds may combine with a number of radioisotopes to be used in cancer therapy and diagnosis. For example, DOTA could act as a chelator for a radionuclide. (Tyr3)-octreotate, a derivative of octreotide, can bind to somatostatin receptors that are found on the cell surfaces of a number of neuroendocrine tumours. Therefore, DOTA-(Tyr3)-Octreotate is able to direct the radioactivity into the tumour.

Re: Chelate Peptides (DOTA related peptides)

Posted by Yasmin Hussain on Jun 16, 2020 10:35 am

Amazing! I also read that cancer cells that express or overexpress specific receptors have led to development of synthetic peptides that target these receptors. Peptides conjugated to metal chelates offer a better approach for imaging of cancer tissues and as therapies that deliver cytotoxic cargo to cancer cells.

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